[LINK] DNA Coil

[stephen at melbpc.org.au]

Wondering about the meaning of life, as you do, I was pondering
the apparent natural affinity many people find with the, 'mortal coil'
metaphor by Shakespeare. Why is it one of his best known quotes
when it doesn't even seem to make much sense? Thus, substitute
'DNA' for 'mortal' and, do a google on, 'DNA Coil' and some great
reading comes up. First wikipedia reminds one of electromagnetic
forces of coils, and then on the major us.gov medical site one reads
research is just now starting on such DNA analysis .. ie, the strands
as a whole electromagnetically .. and more importantly, the gestault
effect.  Any pd across a coil will radiate energy, so what happens in
us electronically if you like when they all fire-up, or are DNA strands
like 'rings on a string' electronically, that's what I'd like to know :)

Google results for 'DNA Coil'

1 http://en.wikipedia.org/wiki/Coil

2: Anantharaman V, (et.al.) Sep 5th, 2006 on: http://www.pubmed.gov

The Signaling Helix: a Common Functional Theme in Diverse Signaling 
Proteins.

ABSTRACT: BACKGROUND: The mechanism by which the signals are transmitted 
between receptor and effector domains in multi-domain signaling proteins 
is poorly understood. 

RESULTS: Using sensitive sequence analysis methods we identify a 
conserved helical segment of around 40 residues in a wide range of 
signaling proteins, including numerous sensor histidine kinases and 
receptor guanylyl cyclases such as the atrial natriuretic peptide 
receptor and nitric oxide receptors. 

We term this helical segment the signaling (S)-helix and present evidence 
that it forms a novel parallel coiled-coil element, distinct from 
previously known helical segments in signaling proteins <snip>

Analysis of domain architectures allowed us to reconstruct the domain-
neighborhood graph for the S-helix, which showed that the S-helix almost 
always occurs between two signaling domains.  

Several striking patterns in the domain neighborhood of the S-helix also 
became evident from the graph <snip>

--
Regards all
Stephen Loosley
Melbourne, Australia