[LINK] O/t cancer breakthrough? CD47

[Robin Whittle]

Hi Stephen,

Thanks for this.

The trick with either attaching an antibody to the CD47 protein or
disabling the macrophage's ability to detect CD47, for the purpose of
making cancer cells more vulnerable to phagocytosis, would be to ensure
there were not significant side effects with the protein's non-cancerous
function, which apparently includes protecting haematopoietic stem cells.

  Please do not eat the stem cells  2009-08-27


http://www.nature.com/stemcells/2009/0908/090827/full/stemcells.2009.116.html


  Hematopoietic stem cells (HSCs) are the blood cells that give
  rise to all the other blood cells.

    http://en.wikipedia.org/wiki/Haematopoietic_stem_cell


  Single antibody shrinks variety of human tumors transplanted
  into mice, study shows  2012-03-26

    http://med.stanford.edu/ism/2012/march/cd47.html


  Biotech company with drug which is intended to disable the
  macrophage's ability to detect CD47 2012-04-04


http://www.prnewswire.com/news-releases/trillium-provides-update-on-anti-cd47-cancer-program-146124925.html


  Pointers to PNAS debate on mechanism, though the papers
  themselves at PNAS are behind a paywall. 2013-03-29


http://www.reddit.com/r/science/comments/1b83sq/evidence_is_not_sufficient_to_support_the_role_of/


  - Robin