[LINK] T cells found in COVID-19 patients ‘bode well’ for long-term immunity

[Stephen Loosley]

T cells found in COVID-19 patients ‘bode well’ for long-term immunity

By Mitch Leslie. May 14, 2020. 9:00 PM  (Science's COVID-19 reporting is supported by the Pulitzer Center.)
https://www.sciencemag.org/news/2020/05/t-cells-found-covid-19-patients-bode-well-long-term-immunity#


Immune warriors known as T cells help us fight off some viruses, but their importance for battling SARS-CoV-2, the virus that causes COVID-19, has been unclear.

Now, two studies reveal that infected people harbor T cells that do target the virus—and may help them recover.

Both studies also found that some people never infected with SARS-CoV-2 have these cellular defences, most likely because they were previously infected with other coronaviruses.

“This is encouraging data,” says virologist Angela Rasmussen of Columbia University.  Although the studies don’t clarify whether people who clear a SARS-CoV-2 infection can then ward off the virus in the future, both identified strong T cell responses to it, which “bodes well for the development of long-term protective immunity,” Rasmussen says.

The findings could also help researchers create better vaccines.

The over 100 COVID-19 vaccines now in development mainly focus on another immune response: antibodies. These proteins are made by B cells and ideally latch onto SARS-CoV-2 and prevent it from entering cells.

T cells, in contrast, thwart infections in two different ways. Helper T cells spur B cells and other immune defenders into action, whereas killer T cells target and destroy infected cells. The severity of disease can depend on the strength of these T cell responses.

Using computer bioinformatics tools, a team led by Shane Crotty and Alessandro Sette, immunologists at the La Jolla Institute for Immunology, predicted which viral protein pieces would provoke the most powerful T cell responses.

They then exposed immune cells from 10 patients who had recovered from mild cases of COVID-19 to these viral snippets.

All of the patients carried helper T cells that recognized the SARS-CoV-2 spike protein, which enables the virus to infiltrate our cells. They also harbored helper T cells that react to other SARS-CoV-2 proteins. And the team detected virus-specific killer T cells in 70% of the subjects, they report today in Cell.  “The immune system sees this virus and mounts an effective immune response,”  Sette says.

The results jibe with those of a study posted as a preprint on medRxiv on 22 April by immunologist Andreas Thiel of the Charité University Hospital in Berlin and colleagues. They identified helper T cells targeting the spike protein in 15 out of 18 patients hospitalized with COVID-19.

The teams also asked whether people who haven’t been infected with SARS-CoV-2 also produce cells that combat it.

Thiel and colleagues analyzed blood from 68 uninfected people, and found that 34% of the blood samples did host helper T cells that recognized SARS-CoV-2. The La Jolla team detected this crossreactivity in about half of stored blood samples collected between 2015 and 2018, well before the current pandemic began.

The researchers think these cells were likely triggered by past infection with one of the four human coronaviruses that cause colds; proteins in these viruses resemble those of SARS-CoV-2.

The results suggest “one reason that a large chunk of the population may be able to deal with the virus is that we may have some small residual immunity from our exposure to common cold viruses,” says viral immunologist Steven Varga of the University of Iowa ...

--