[LINK] Accidental intravenous injection of AstraZenica as potential mechanism for post-vaccination TTS.

[Peter Batchelor]

Norman Swan was talking about this on CoronaCast late last week. The research was yet to be peer reviewed, but he referred to his training in giving intramuscular injections, where you had to draw back to check that there was no blood.
Peter

> On 5 Jul 2021, at 12:35 pm, Jan Whitaker <jwhit at internode.on.net> wrote:
> 
> Interesting! Someone who I think was a nurse, can't remember who, was appalled that the injections were NOT being pulled back to be sure there was no blood. They were watching the endless TV videos of injections being given. From this article, it seems they were on to something.
> 
> Jan
> 
> On 5/07/2021 11:05 am, Kim Holburn wrote:
>> https://www.biorxiv.org/content/10.1101/2021.06.29.450356v1.abstract
>> 
>> Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration.
>> 
>>> Vaccines against SARS-CoV-2 are based on a range of novel vaccine platforms, with adenovirus-based approaches (like ChAdOx1 nCov-19) being one of them. Recently a rare and novel complication of SARS-CoV-2 targeted adenovirus vaccines has emerged: thrombosis with thrombocytopenia syndrome (TTS). TTS is characterized by low platelet counts, clot formation at unusual anatomic sites and platelet-activating PF4-polyanion antibodies reminiscent of heparin-induced thrombocytopenia. Here, we employ /in vitro/ and /in vivo/ models to characterize the possible mechanisms of this platelet-targeted autoimmunity. We show that intravenous but not intramuscular injection of ChAdOx1 nCov-19 triggers platelet-adenovirus aggregate formation and platelet activation. After intravenous injection, these aggregates are phagocytosed by macrophages in the spleen and platelet remnants are found in the marginal zone and follicles. This is followed by a pronounced B-cell response with the emergence of circulating antibodies binding to platelets. Our work contributes to the understanding of TTS and highlights accidental intravenous injection as potential mechanism for post-vaccination TTS. Hence, safe intramuscular injection, with aspiration prior to injection, could be a potential preventive measure when administering adenovirus-based vaccines.
>> 
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