[LINK] Accidental intravenous injection of AstraZenica as potential mechanism for post-vaccination TTS.

[Jan Whitaker]

Interesting! Someone who I think was a nurse, can't remember who, was 
appalled that the injections were NOT being pulled back to be sure there 
was no blood. They were watching the endless TV videos of injections 
being given. From this article, it seems they were on to something.

Jan

On 5/07/2021 11:05 am, Kim Holburn wrote:
> https://www.biorxiv.org/content/10.1101/2021.06.29.450356v1.abstract
>
> Thrombocytopenia and splenic platelet directed immune responses after 
> intravenous ChAdOx1 nCov-19 administration.
>
>> Vaccines against SARS-CoV-2 are based on a range of novel vaccine 
>> platforms, with adenovirus-based approaches (like ChAdOx1 nCov-19) 
>> being one of them. Recently a rare and novel complication of 
>> SARS-CoV-2 targeted adenovirus vaccines has emerged: thrombosis with 
>> thrombocytopenia syndrome (TTS). TTS is characterized by low platelet 
>> counts, clot formation at unusual anatomic sites and 
>> platelet-activating PF4-polyanion antibodies reminiscent of 
>> heparin-induced thrombocytopenia. Here, we employ /in vitro/ and /in 
>> vivo/ models to characterize the possible mechanisms of this 
>> platelet-targeted autoimmunity. We show that intravenous but not 
>> intramuscular injection of ChAdOx1 nCov-19 triggers 
>> platelet-adenovirus aggregate formation and platelet activation. 
>> After intravenous injection, these aggregates are phagocytosed by 
>> macrophages in the spleen and platelet remnants are found in the 
>> marginal zone and follicles. This is followed by a pronounced B-cell 
>> response with the emergence of circulating antibodies binding to 
>> platelets. Our work contributes to the understanding of TTS and 
>> highlights accidental intravenous injection as potential mechanism 
>> for post-vaccination TTS. Hence, safe intramuscular injection, with 
>> aspiration prior to injection, could be a potential preventive 
>> measure when administering adenovirus-based vaccines.
>